Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Oncogenic Viruses Service, National and Regional HPV Reference Laboratory, National Institute of Infectious Diseases - ANLIS "Dr. Carlos G. Malbrán", Buenos Aires, Argentina.
Braz J Med Biol Res. 2020 Jan 31;53(2):e9560. doi: 10.1590/1414-431X20199560. eCollection 2020.
Our aim was to review the major contributions of studies conducted in different Latin American (LA) countries to the field of human papillomavirus (HPV) epidemiology, natural history, risk of disease, and prevention strategies, mainly in the uterine cervix. Although cytological screening is established in several countries in LA, incidence and mortality rates from cervical cancer (CC) are still extremely high. Finally, data from large cohort studies conducted in LA countries provided seminal data to propose primary and secondary prevention modalities: the HPV vaccine has been introduced in the national immunization programs of several LA countries and multiple screening experiences using HPV testing are under evaluation in the region.
我们的目的是回顾在不同拉丁美洲（LA）国家进行的研究在人乳头瘤病毒（HPV）流行病学、自然史、疾病风险和预防策略方面的主要贡献，主要集中在子宫颈。尽管细胞学筛查在几个 LA 国家已经建立，但宫颈癌（CC）的发病率和死亡率仍然极高。最后，LA 国家的大型队列研究提供了重要数据，提出了初级和二级预防方法：HPV 疫苗已被引入几个 LA 国家的国家免疫计划，该地区正在评估使用 HPV 检测的多种筛查经验。
