Kasai H, Yamaizumi Z, Yamamoto F, Bessho T, Nishimura S, Berger M, Cadet J
Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
Nucleic Acids Symp Ser. 1992(27):181-2.
Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.
