Sarandöl Emre, Dirican Melahat, Serdar Zehra
Department of Biochemistry, Medical Faculty, Uludağ University, 16059 Görükle, Bursa, Turkey.
Arch Gynecol Obstet. 2004 Nov;270(3):157-60. doi: 10.1007/s00404-003-0524-7. Epub 2003 Aug 6.
The object was to assess oxidizability of apolipoprotein B-containing lipoproteins, levels of lipid peroxidation products and antioxidants in normal pregnancy.
Serum malondialdehyde, vitamin E, carotenoids, albumin, uric acid, bilirubin, triglyceride, total cholesterol levels and in vitro copper-induced oxidation of apolipoprotein B-containing lipoproteins were investigated in 21 healthy pregnant and 22 nonpregnant women. Mann-Whitney U test was used for the statistical analyses.
Serum malondialdehyde, vitamin E, triglyceride and total cholesterol levels were significantly higher; albumin and uric acid levels and vitamin E/triglyceride + total cholesterol and carotenoids/triglyceride + total cholesterol ratios were significantly lower in the pregnant group. Basal malondialdehyde concentrations of apolipoprotein B-containing lipoprotein fraction and Delta-malondialdehyde values determined at 30, 60, 90, 120, 150 and 180th minutes of incubation were significantly lower in the pregnant group compared to those in the non-pregnant group.
Although greater lipid peroxidation product levels reflect an enhanced lipid peroxidation status in normal pregnancy, apolipoprotein B-containing lipoprotein fraction of normal pregnant women compared with the nonpregnant subjects seems to be protected from oxidation.
本研究旨在评估正常妊娠期间含载脂蛋白B的脂蛋白的氧化能力、脂质过氧化产物水平及抗氧化剂水平。
对21名健康孕妇和22名非孕妇进行血清丙二醛、维生素E、类胡萝卜素、白蛋白、尿酸、胆红素、甘油三酯、总胆固醇水平及含载脂蛋白B的脂蛋白的体外铜诱导氧化研究。采用曼-惠特尼U检验进行统计学分析。
孕妇组血清丙二醛、维生素E、甘油三酯和总胆固醇水平显著升高；白蛋白和尿酸水平以及维生素E/甘油三酯+总胆固醇和类胡萝卜素/甘油三酯+总胆固醇比值显著降低。与非孕妇组相比，孕妇组含载脂蛋白B的脂蛋白组分的基础丙二醛浓度以及在孵育30、60、90、120、150和180分钟时测定的丙二醛增加值均显著降低。
尽管较高的脂质过氧化产物水平反映了正常妊娠期间脂质过氧化状态增强，但与非孕妇相比，正常孕妇含载脂蛋白B的脂蛋白组分似乎受到氧化保护。
