Tong Yin, Jin Jie, Yan Lixing, Neppert Jürgen, Marget Matthias, Flesch Brigitte K
Department of Hematology, 1st Affiliated Hospital of Zhejiang University, Zhejiang, China.
Ann Hematol. 2003 Sep;82(9):574-8. doi: 10.1007/s00277-003-0725-y. Epub 2003 Aug 6.
The human neutrophil antigens HNA-1a, -1b and -1c play an important role in immune neutropenia. The frequencies of the coding FCGR3B genes were determined in different populations. New FCGR3B variants were also found in some populations. This study investigated the FCGR3B gene frequencies and FCGR3 variants in a Chinese population compared with the results of Northern Germans and African Blacks (Uganda). Our results show that the gene frequencies in 413 healthy Chinese individuals from Zhejiang Province were 0.565 for FCGR3B1, 0.430 for FCGR3B2 and 0.00 for FCGR3B3. The genotype frequency of FCGR3B(null) was 0.48% (2/413). Sequencing of FCGR3 revealed that in seven out of 19 Chinese individuals, cloned and sequenced DNA fragments that exhibited variants caused by single nucleotide exchanges at one or more of the polymorphic positions 141, 147, 227, 266 and 277 in exon 3 also existed in this Chinese population. From the present study, it is concluded that the FCGR3B1 gene is more frequent in a Chinese population from Zhejiang Province than the FCGR3B2 gene, and the FCGR3B3 gene seems to be absent, which is in contrast to studies in the white populations. Gene variants caused by single nucleotide exchanges were found in addition to the well-known forms, but the reason for this remains unclear.
人类中性粒细胞抗原HNA-1a、-1b和-1c在免疫性中性粒细胞减少症中起重要作用。已测定不同人群中编码FCGR3B基因的频率。在一些人群中还发现了新的FCGR3B变体。本研究调查了中国人群中的FCGR3B基因频率和FCGR3变体，并与德国北部人群和非洲黑人（乌干达）的结果进行比较。我们的结果显示，来自浙江省的413名健康中国人中，FCGR3B1的基因频率为0.565，FCGR3B2的基因频率为0.430，FCGR3B3的基因频率为0.00。FCGR3B(null)的基因型频率为0.48%（2/413）。FCGR3测序显示，在19名中国人中的7名中，克隆并测序的DNA片段在第3外显子的141、147、227、266和277一个或多个多态性位置存在由单核苷酸交换引起的变体，该变体在该中国人群中也存在。从本研究可以得出结论，浙江省中国人群中FCGR3B1基因比FCGR3B2基因更常见，且似乎不存在FCGR3B3基因，这与白人人群的研究结果相反。除了已知形式外，还发现了由单核苷酸交换引起的基因变体，但其原因尚不清楚。
