Takenaka S, Nishira S, Kondo H, Takagi M
Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, Japan.
Nucleic Acids Symp Ser. 1992(27):71-2.
Novel DNA binding ligands (1 and its stereoisomer 2) which contain three potentially intercalating units in a linear molecular skeleton were prepared. From a study of the displacement of ethidium bromide from several natural and synthetic polynucleotides, both compounds 1 and 2 were found to show an AT base-pair preference in the interaction with DNAs with 2 a slightly higher affinity for DNA. This result is in sharp contrast to that for acridine and anthraquinone, because these two compounds exhibit a GC-preference.
制备了在直链分子骨架中含有三个潜在嵌入单元的新型DNA结合配体（1及其立体异构体2）。通过研究溴化乙锭从几种天然和合成多核苷酸中的位移发现，化合物1和2在与DNA相互作用时均表现出对AT碱基对的偏好，其中2对DNA的亲和力略高。该结果与吖啶和蒽醌的结果形成鲜明对比，因为这两种化合物表现出对GC的偏好。
