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[口腔黏膜组织结构及DNA修复能力的年龄相关性变化研究]

[A study on age-related changes of histological structure and DNA repair capacity in oral mucosa].

作者信息

Zhou Hongmei, Yang Ya, Zhou Min

机构信息

Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2003 Jun;21(3):177-9.

PMID:12898754
Abstract

OBJECTIVE

To investigate the age-related changes of histological structure and DNA repair capacity (P53 protein expression) in oral mucous membrane and try to explain why the elders are prone to oral squamous cell carcinoma.

METHODS

The routine HE staining and an immunohistochemical technical (SP method) were used respectively to study the changes of histological structure and P53 expression in normal oral mucosa of different age groups. The SP staining results were evaluated by semiquantity method.

RESULTS

  1. With aging, a series of histological changes were observed in the oral mucosa; 2. With aging, an elevating tendency of P53 protein level emerged in the oral mucosa (P < 0.05).

CONCLUSION

The sensitivity to carcinogenic agents in elder people may be accentuated by the age-related histological changes and DNA repair capacity changes of the normal oral mucosa.

摘要

目的

研究口腔黏膜组织结构及DNA修复能力（P53蛋白表达）的年龄相关性变化，并试图解释老年人易患口腔鳞状细胞癌的原因。

方法

分别采用常规HE染色和免疫组织化学技术（SP法）研究不同年龄组正常口腔黏膜组织结构变化及P53表达情况。采用半定量法评估SP染色结果。

结果

  1. 随着年龄增长，口腔黏膜出现一系列组织学变化；2. 随着年龄增长，口腔黏膜中P53蛋白水平呈上升趋势（P < 0.05）。

结论

正常口腔黏膜的年龄相关性组织学变化及DNA修复能力变化可能会增强老年人对致癌剂的敏感性。

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