Yang Ya, Zhou Hongmei, Zhou Min, Liu Ying, He Zhixiu, Li Bingqi
Oral Medicine Research Laboratory, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):513-5, 564.
To investigate the age-related changes of P53 protein expression in oral mucous membrane and their effects on pathogenesis of the oral precancerous lesions in elderly people.
An immunohistochemical technique (SP method) was applied to study the changes of P53 expression in normal oral mucosa and oral leukoplakia(OLK) in different age groups. The staining results were evaluated by semi-quantity method.
With aging, an elevating tendency of P53 protein level exhibited in the normal oral mucosa and OLK, respectively. The P53 level in the old with OLK was higher than that in the normal oral mucosa of the old (P < 0.01).
With aging, P53 protein may undergo dysfunction, lead to imperfect DNA repair and excessive DNA damage accumulation, and ultimately facilitate malignant transformation of the oral mucosa in the old.
探讨老年人口腔黏膜中P53蛋白表达的年龄相关变化及其对口腔癌前病变发病机制的影响。
应用免疫组织化学技术（SP法）研究不同年龄组正常口腔黏膜和口腔白斑（OLK）中P53表达的变化。采用半定量法评估染色结果。
随着年龄增长，正常口腔黏膜和OLK中P53蛋白水平均呈上升趋势。老年OLK患者的P53水平高于老年正常口腔黏膜患者（P < 0.01）。
随着年龄增长，P53蛋白可能发生功能障碍，导致DNA修复不完善和DNA损伤过度积累，最终促进老年人口腔黏膜的恶性转化。
