Jianchuan X, Song L, Jianhua Z, Xiaoming N, Quanzhang L, Pu L
Laboratory of Medical Genetics, Basic Medical College of Harbin Medical University, Harbin 150086.
Chin Med Sci J. 1999 Mar;14(1):7-12.
Direct chromosome analysis and FISH were performed on twelve primary gastric carcinomas. Two of them had simple chromosome changes: 48, XX, +8, +20, and 49, XY, +2, +8, +9, and the others had complicated chromosome changes, which includes much more numerical and structural chromosome aberrations. Frequent structural changes in the complicated types involved chromosome 7, 3, 1, 5 and 12 etc. The del 7q was noted in eight cases. The del (3p) and del (1p) were noted in six and five cases, respectively. The results provide some important clues for isolation of the genes related to gastric cancer.
对12例原发性胃癌进行了直接染色体分析和荧光原位杂交（FISH）。其中2例有简单的染色体改变：48, XX, +8, +20和49, XY, +2, +8, +9，其他病例有复杂的染色体改变，包括更多的染色体数目和结构畸变。复杂类型中常见的结构改变涉及7号、3号、1号、5号和12号染色体等。8例出现7号染色体长臂缺失（del 7q）。分别有6例和5例出现3号染色体短臂缺失（del (3p)）和1号染色体短臂缺失（del (1p)）。这些结果为分离与胃癌相关的基因提供了一些重要线索。
