Vaidya Sagar A, Cheng Genhong
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 90095, USA.
Curr Opin Immunol. 2003 Aug;15(4):402-7. doi: 10.1016/s0952-7915(03)00070-0.
Toll-like receptors (TLRs) have a unique and important role in detecting the presence of pathogenic infection. TLRs can recognize conserved structures from a wide variety of microorganisms, such as bacteria, mycobacteria, spirochetes and yeast. However, they are generally not thought to play a major role in viral infection. Several reports have now identified distinct viral ligands for the TLRs, and evidence is accumulating for a functional role of the TLRs in mediating antiviral effector mechanisms.
Toll样受体（TLRs）在检测病原感染的存在方面具有独特而重要的作用。TLRs能够识别多种微生物的保守结构，如细菌、分枝杆菌、螺旋体和酵母。然而，一般认为它们在病毒感染中不发挥主要作用。现在已有数份报告鉴定出TLRs的不同病毒配体，并且越来越多的证据表明TLRs在介导抗病毒效应机制中具有功能性作用。
