成都人群中IDDM3、IDDM4、IDDM5和IDDM8与胰岛素依赖型糖尿病关联的初步研究。
Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population.
作者信息
Zhoucun A, Zhang S, Xiao C
机构信息
Department of Medical Genetics, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041.
出版信息
Chin Med Sci J. 2001 Jun;16(2):120-2.
OBJECTIVE
To study the associations of IDDM3, IDDM4, IDDM5 and IDDM8 with insulin-dependent diabetes mellitus (IDDM).
METHODS
The polymorphisms of short tandem repeat (STR) loci D15S657, D11S1369, D6S2420 and D6S503, linked to IDDM3, IDDM4, IDDM5 and IDDM8 respectively, were studied by polymerase chain reaction and polyacrylamide gel electrophoresis (PCR-PAGE) followed by direct sequencing of PCR products in 105 normal Chinese Han nationality subjects and 48 patients with IDDM.
RESULTS
The allele frequencies of allele A5 at D15S657 locus, allele A5 at D11S1369 locus and allele A4 at D6S2420 locus were increased significantly in patients with IDDM compared to those in the control group. No difference in the allele frequencies at D6S503 locus was observed between IDDM and control group.
CONCLUSION
IDDM3, IDDM4, IDDM5 but not IDDM8 may be associated with IDDM in Chinese Han nationality population.
目的
研究IDDM3、IDDM4、IDDM5和IDDM8与胰岛素依赖型糖尿病（IDDM）的相关性。
方法
分别与IDDM3、IDDM4、IDDM5和IDDM8连锁的短串联重复序列（STR）位点D15S657、D11S1369、D6S2420和D6S503的多态性，采用聚合酶链反应和聚丙烯酰胺凝胶电泳（PCR-PAGE）进行研究，随后对105名正常中国汉族受试者和48名IDDM患者的PCR产物进行直接测序。
结果
与对照组相比，IDDM患者中D15S657位点的A5等位基因频率、D11S1369位点的A5等位基因频率和D6S2420位点的A4等位基因频率显著增加。IDDM组和对照组在D6S503位点的等位基因频率未观察到差异。
结论
在中国汉族人群中，IDDM3、IDDM4、IDDM5可能与IDDM相关，而IDDM8则不然。
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