一个新的胰岛素依赖型糖尿病易感性基因（IDDM8）在6号染色体q25-q27区域的受累同胞对定位研究。
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.
作者信息
Luo D F, Bui M M, Muir A, Maclaren N K, Thomson G, She J X
机构信息
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610, USA.
出版信息
Am J Hum Genet. 1995 Oct;57(4):911-9.
Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages.
采用104个高加索家庭进行了受累同胞对分析，以定位易患胰岛素依赖型糖尿病（IDDM）的基因。我们在6q25 - q27区域获得了D6S446（最大对数优势分数[MLS]=2.8）和D6S264（MLS = 2.0）的连锁证据。结合之前报道的数据集，可以确定连锁关系（D6S264的MLS = 3.4），该疾病位点已被命名为IDDM8。通过对独立家庭的分析，我们证实了之前确定的IDDM3（15q）和IDDM7（2q）的连锁证据。我们还在包含IDDM3、IDDM4、IDDM5和IDDM8的区域中检测了其他标记。在47个佛罗里达家庭中发现了4号染色体q区域（D4S1566）一个新区域的初步连锁证据（P < 0.03）。我们还发现了之前在佛罗里达亚组中被确定为潜在连锁区域的两个区域的连锁证据：3q上的D3S1303（P < 0.04）和7q上的D7S486（P < 0.03）。我们无法证实与之前确定为潜在连锁区域的其他八个区域（D1S191、D1S412、D4S1604、D8S264、D8S556、D10S193、D13S158和D18S64）的连锁关系。
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