Stittelaar Koert J, de Swart Rik L, Osterhaus Albert D M E
Institute of Virology, Erasmus MC, Rotterdam, The Netherlands.
Expert Rev Vaccines. 2002 Aug;1(2):151-9. doi: 10.1586/14760584.1.2.151.
Measles, a highly contagious viral disease, is a major childhood killer in developing countries, accounting for almost 1 million deaths every year globally. Measles virus normally does not cause a persistent infection, no animal reservoir for measles virus exists, no vector is involved in its spread, only one serotype exists, the virus is antigenically stable and vaccination with the currently used live attenuated vaccines proved to be highly effective in preventing disease. Therefore, theoretically measles should be considered eradicable. This article provides a review of past and current measles vaccination efforts and development and need of new generation experimental measles vaccines.
麻疹是一种极具传染性的病毒性疾病，是发展中国家儿童的主要杀手，全球每年约有100万人死于麻疹。麻疹病毒通常不会引起持续性感染，不存在麻疹病毒的动物宿主，其传播不涉及媒介，只有一种血清型，该病毒抗原稳定，目前使用的减毒活疫苗接种证明对预防疾病非常有效。因此，从理论上讲，麻疹应被视为可根除的疾病。本文综述了过去和当前的麻疹疫苗接种工作以及新一代实验性麻疹疫苗的研发情况和需求。
