设计针对引起慢性疾病的细胞内病原体的有效疫苗接种需要哪些信息？

What information is needed to design effective vaccination against intracellular pathogens causing chronic disease?

作者信息

Bretscher Peter A, Hamilton Duane, Ogunremi Oladele

机构信息

Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada.

出版信息

Expert Rev Vaccines. 2002 Aug;1(2):179-92. doi: 10.1586/14760584.1.2.179.

DOI:10.1586/14760584.1.2.179

PMID:12901557

Abstract

An appreciation of global features of immune regulation may lead to vaccination strategies effective in a genetically diverse population against a number of intracellular pathogens that cause chronic disease. Such global strategies appear more straightforward than strategies requiring a detailed knowledge of the specificity of 'protective T-cells'. Global strategies may be effective against the virus, bacteria and protozoa that respectively cause AIDS, tuberculosis and the leishmaniases.

摘要

了解免疫调节的整体特征可能会催生一些疫苗接种策略，这些策略在基因多样化的人群中对于多种导致慢性病的细胞内病原体有效。与那些需要详细了解“保护性T细胞”特异性的策略相比，此类整体策略似乎更为直接。整体策略可能对分别导致艾滋病、结核病和利什曼病的病毒、细菌和原生动物有效。