Partidos Charalambos D
UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F-67084 Strasbourg, France.
Expert Rev Vaccines. 2003 Dec;2(6):753-61. doi: 10.1586/14760584.2.6.753.
The skin is a highly accessible organ and due to the presence of powerful antigen-presenting cells in the epidermis, it functions as an immune barrier. This makes the skin an attractive route for potential delivery of vaccines by painless and user-friendly methods without the requirement of needles and syringes. This article reviews current attempts to administer vaccines into the skin and discusses some of the scientific issues related to the emerging delivery technologies.
皮肤是一个极易接触到的器官，由于表皮中存在强大的抗原呈递细胞，它起着免疫屏障的作用。这使得皮肤成为通过无痛且用户友好的方法（无需针头和注射器）潜在递送疫苗的有吸引力途径。本文综述了目前将疫苗接种到皮肤的尝试，并讨论了与新兴递送技术相关的一些科学问题。
