Pardoe Ian, Dargan Derrick
Henderson Morley plc, Brimingham, UK.
Expert Rev Vaccines. 2002 Dec;1(4):427-32. doi: 10.1586/14760584.1.4.427.
Conventional virus-like particles are usually composed of a single structural protein which spontaneously assembles into particles. L-particles, a little-known type of virus-like particle, are produced as part of the natural infectious process of many, if not all, alpha-herpesviruses. L-particles lack the nucleocapsid present in the infectious virion but contain all of the virus envelope and tegument proteins. L-particles contain no virus DNA and are noninfectious, though they are biologically competent, since they are capable of delivering viral envelope and tegument proteins to cells. When cells are infected with herpes simplex virus Type 1 under conditions where viral DNA synthesis is blocked, previral DNA replication enveloped particles are produced. These are similar to L-particles, but differ slightly in protein composition. This article reviews the available data regarding these vaccine candidates and explores the wide-ranging potential applications, including vaccine candidates against infectious diseases and cancer, as well as a protein delivery vector.
传统的病毒样颗粒通常由单一结构蛋白组成，该蛋白可自发组装成颗粒。L颗粒是一种鲜为人知的病毒样颗粒类型，是许多（如果不是所有）α疱疹病毒自然感染过程的一部分。L颗粒缺乏感染性病毒体中存在的核衣壳，但包含所有病毒包膜和被膜蛋白。L颗粒不含病毒DNA且无感染性，尽管它们具有生物学活性，因为它们能够将病毒包膜和被膜蛋白递送至细胞。当细胞在病毒DNA合成受阻的条件下感染1型单纯疱疹病毒时，会产生病毒前DNA复制包膜颗粒。这些颗粒与L颗粒相似，但蛋白质组成略有不同。本文综述了有关这些候选疫苗的现有数据，并探讨了其广泛的潜在应用，包括针对传染病和癌症的候选疫苗，以及一种蛋白质递送载体。
