Rouse Barry T, Kaistha Shilpa Deshpande
Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Clin Infect Dis. 2006 Mar 15;42(6):810-7. doi: 10.1086/500141. Epub 2006 Feb 8.
Of the 8 known herpesviruses that affect human beings, we only have successful vaccines against varicella zoster virus. This brief review compares the pathogenesis of varicella zoster virus with that of the closely related alpha-herpesviruses herpes simplex virus 1 and 2, for which we have no satisfactory vaccines. The main objective of this review is to learn lessons from the success of varicella zoster virus vaccine that could be exploited for the development of successful vaccines against herpes simplex virus and perhaps against other herpes viruses.
在已知的8种感染人类的疱疹病毒中，我们仅拥有针对水痘带状疱疹病毒的成功疫苗。这篇简短的综述将水痘带状疱疹病毒的发病机制与密切相关的α疱疹病毒单纯疱疹病毒1型和2型的发病机制进行了比较，对于这两种病毒我们尚无令人满意的疫苗。本综述的主要目的是从水痘带状疱疹病毒疫苗的成功中吸取经验教训，这些经验可用于开发针对单纯疱疹病毒乃至其他疱疹病毒的成功疫苗。
