Yang Eric V, Glaser Ronald
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA.
Expert Rev Vaccines. 2002 Dec;1(4):453-9. doi: 10.1586/14760584.1.4.453.
The rapidly growing field of psychoneuroimmunology involves the elucidation of the complex interactions between the CNS, the endocrine system and the immune system and its effects on health. Although the mechanisms involved in this bidirectional communication is not yet fully understood, studies in psychoneuroimmunology have shown that stress, through the hypothalamic-pituitary-adrenal and the sympathetic-adrenal-medullary axes, can induce modulation of the immune system. In this review, we discuss human studies and animal models, which focus on psychological stress and its effects on the immune response to vaccination, emphasizing the implications of these effects on health.
迅速发展的心理神经免疫学领域涉及阐明中枢神经系统、内分泌系统和免疫系统之间的复杂相互作用及其对健康的影响。尽管这种双向通信所涉及的机制尚未完全了解，但心理神经免疫学的研究表明，压力通过下丘脑 - 垂体 - 肾上腺轴和交感 - 肾上腺 - 髓质轴，可以诱导免疫系统的调节。在这篇综述中，我们讨论了人类研究和动物模型，它们聚焦于心理压力及其对疫苗接种免疫反应的影响，强调了这些影响对健康的意义。
