心理压力对免疫调节平衡的不良影响：在人类炎症性疾病中的应用。
The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.
机构信息
Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, 2500 North State Street N416, Jackson, MS 39216-4505, USA.
出版信息
Immunol Allergy Clin North Am. 2011 Feb;31(1):133-40. doi: 10.1016/j.iac.2010.09.013.
Abstract
Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.
摘要
心理压力对免疫系统有已知的影响，包括影响效应器和调节成分。这可能导致对各种感染的易感性增加、潜伏病毒再激活以及对免疫调节回路的影响。转化研究中的一个巨大挑战是确定特定患者人群和个体中与压力相关的风险。未来的研究必须包括鉴定和验证生物标志物，这些标志物可以将患者因各种形式和程度的心理压力而产生不良免疫效应的风险进行分类，以及这如何影响他们炎症性疾病的进程。
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本文引用的文献
1
Immunomodulatory effects of in vitro stress hormones on FoxP3, Th1/Th2 cytokine and costimulatory molecule mRNA expression in human peripheral blood mononuclear cells.体外应激激素对人外周血单个核细胞 FoxP3、Th1/Th2 细胞因子和共刺激分子 mRNA 表达的免疫调节作用。
Neuroimmunomodulation. 2011;18(1):1-10. doi: 10.1159/000311450. Epub 2010 Jul 7.
2
FOXP3+ regulatory T cells in the human immune system.FOXP3+ 调节性 T 细胞在人类免疫系统中的作用。
Nat Rev Immunol. 2010 Jul;10(7):490-500. doi: 10.1038/nri2785. Epub 2010 Jun 18.
3
Identifying the stress-susceptible patient at risk for inflammatory diseases: an interdisciplinary approach.识别易患炎症性疾病的应激易感患者：一种跨学科方法。
Expert Rev Clin Immunol. 2009 Mar;5(2):119-21. doi: 10.1586/1744666X.5.2.119.
4
5
Neuroimmune interactions in stress.神经免疫相互作用与应激。
Neuroimmunomodulation. 2010;17(3):196-9. doi: 10.1159/000258722. Epub 2010 Feb 4.
6
Impact of psychosocial risk factors on the heart: changing paradigms and perceptions.心理社会风险因素对心脏的影响：改变范式和观念。
Phys Sportsmed. 2009 Oct;37(3):35-7. doi: 10.3810/psm.2009.10.1727.
7
Decrease of CD4(+)FOXP3(+) T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor.在经历精神应激的人体外周血中，CD4(+)FOXP3(+) T 调节细胞减少。
Psychoneuroendocrinology. 2010 Jun;35(5):663-73. doi: 10.1016/j.psyneuen.2009.10.005. Epub 2009 Dec 16.
8
Current perspectives of the roles of the central norepinephrine system in anxiety and depression.中枢去甲肾上腺素系统在焦虑和抑郁中的作用的当前观点。
Depress Anxiety. 2010 Apr;27(4):339-50. doi: 10.1002/da.20642.
9
Stress and autoimmunity.压力与自身免疫。
Autoimmun Rev. 2010 Mar;9(5):A271-6. doi: 10.1016/j.autrev.2009.11.014. Epub 2009 Nov 27.
10
Maternal interpersonal trauma and cord blood IgE levels in an inner-city cohort: a life-course perspective.城市内部队列中母亲人际创伤与脐带血IgE水平：一种生命历程视角
J Allergy Clin Immunol. 2009 Nov;124(5):954-60. doi: 10.1016/j.jaci.2009.07.030. Epub 2009 Sep 12.
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