心理压力对免疫调节平衡的不良影响：在人类炎症性疾病中的应用。
The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.
机构信息
Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, 2500 North State Street N416, Jackson, MS 39216-4505, USA.
出版信息
Immunol Allergy Clin North Am. 2011 Feb;31(1):133-40. doi: 10.1016/j.iac.2010.09.013.
Abstract
Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.
摘要
心理压力对免疫系统有已知的影响，包括影响效应器和调节成分。这可能导致对各种感染的易感性增加、潜伏病毒再激活以及对免疫调节回路的影响。转化研究中的一个巨大挑战是确定特定患者人群和个体中与压力相关的风险。未来的研究必须包括鉴定和验证生物标志物，这些标志物可以将患者因各种形式和程度的心理压力而产生不良免疫效应的风险进行分类，以及这如何影响他们炎症性疾病的进程。
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