Verstraeten Thomas, DeStefano Frank, Chen Robert T, Miller Elizabeth
GlaxoSmithKline Biologicals, Rixensart, Belgium.
Expert Rev Vaccines. 2003 Feb;2(1):21-9. doi: 10.1586/14760584.2.1.21.
Combined administrative databases are referred to as 'large linked databases' because of their relatively large size and the need for linkage of different data sets that were created separately from each other. Such linked databases have become popular in vaccine safety surveillance. Whereas their use offers some unique opportunities, their increasingly widespread use can also lead to wrongful linkage of vaccines to adverse events. We review the opportunities and hazards of using large linked databases for vaccine safety surveillance and propose some guidelines to increase the reliability of the outcomes. We also offer our opinion on the future use of large linked databases for vaccine safety surveillance purposes.
联合管理数据库因其规模相对较大以及需要将彼此独立创建的不同数据集进行链接而被称为“大型链接数据库”。此类链接数据库在疫苗安全性监测中已变得很常见。尽管其使用提供了一些独特的机会，但它们越来越广泛的使用也可能导致疫苗与不良事件的错误关联。我们回顾了使用大型链接数据库进行疫苗安全性监测的机会和风险，并提出了一些提高结果可靠性的指南。我们还对大型链接数据库未来用于疫苗安全性监测的用途发表了看法。
