Moore George E, Ward Michael P, Kulldorff Martin, Caldanaro Richard J, Guptill Lynn F, Lewis Hugh B, Glickman Lawrence T
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USA.
Vaccine. 2005 Dec 1;23(48-49):5557-62. doi: 10.1016/j.vaccine.2005.07.041. Epub 2005 Aug 8.
Electronic medical records of a large veterinary practice were used for surveillance of potential space-time clustering of adverse events associated with rabies vaccination in dogs. The study population was 257,564 dogs vaccinated in 169 hospitals in 13 US metropolitan areas during a 24-month period. Using a scan statistic for population rate data, significant space-time clusters were identified involving the Atlanta and Tampa/St. Petersburg areas during a 4-month period. Separate spatial-temporal analyses of these cities using coordinates for individual address coordinates identified one significant patient cluster (P=0.002), associated with a 23.26 km-radius area in Atlanta (20 adverse events in 702 dogs; 2.85%) from November 2002 through February 2003. This percentage of adverse events was significantly increased after adjustment for host-related factors and the number of concurrent vaccinations.
一家大型兽医诊所的电子病历被用于监测犬类狂犬病疫苗接种相关不良事件的潜在时空聚集情况。研究对象为在24个月期间内，美国13个大都市地区169家医院接种疫苗的257,564只犬。使用针对人群发病率数据的扫描统计方法，在4个月期间识别出涉及亚特兰大及坦帕/圣彼得斯堡地区的显著时空聚集。利用各个地址坐标的坐标对这些城市进行单独的时空分析，确定了一个显著的患者聚集区（P = 0.002），该区域位于亚特兰大，半径为23.26公里（702只犬中有20起不良事件；2.85%），时间跨度为2002年11月至2003年2月。在对宿主相关因素和同时接种疫苗的数量进行调整后，不良事件的这一百分比显著增加。
