Li Chi-Yuan, Wang Yvonne, Hu Ming-Kuan
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, 325, Chenggung Road, Section 2, 114, Taipei, Taiwan.
Bioorg Med Chem. 2003 Aug 15;11(17):3665-71. doi: 10.1016/s0968-0896(03)00348-1.
We reported the discovery of potent antioxidants based on magnolol, a naturally occurring biphenolic obtained from the bark of Magnolia officinalis. The allylmagnolols 3a,b were synthesized via O-alkylation of the biphenols followed by Claisen rearrangement. In-vitro using enhanced chemiluminescence (CL) and flow cytometric assays in whole cells revealed that both 3a and 3b displayed promising free radical scavenging effects in PMA- and LPS-stimulated models as compared with magnolol. Further DNA labeling analysis for cytotoxicity indicated that these analogues show no cytotoxic effects for the scavenging of the oxygen-derived free radicals under PMA-stimulated concentrations. The results from 3,3'-bisallylmagnolol (3b) suggested that the naturally occurring constituent was suitable to be a lead compound for the development of potential antioxidants for certain diseases.
