Shen Chien-Chang, Ni Ching-Li, Shen Yuh-Chiang, Huang Yu-Ling, Kuo Ching-Hsia, Wu Tian-Shung, Chen Chien-Chih
National Research Institute of Chinese Medicine, Taipei, 112, Taiwan, Republic of China.
J Nat Prod. 2009 Jan;72(1):168-71. doi: 10.1021/np800494e.
Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2-8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4-7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.
从厚朴茎皮水提取物的甲醇可溶部分中分离出三种新化合物，厚朴内酯（1）、赤式和厚朴三醇（2）以及苏式和厚朴三醇（3），以及14种已知化合物，厚朴醛（4）、厚朴三醇B（5）、兰代醇（6）、倒卵叶木兰脂素（7）、厚朴木脂素B（8a和8b）、厚朴酚、和厚朴酚（9）、对羟基苯甲醛、松柏醛、松柏醇、丁香醛、丁香树脂酚和毛蕊花糖苷。在这些化合物中，对2 - 8b进行了抗炎和抗氧化活性研究。化合物7显示出比9更强的抗氧化潜力。化合物4 - 7有效抑制脂多糖诱导的一氧化氮产生，而5和6比9更有效。
