Papp Balázs, Pál Csaba, Hurst Laurence D
Department of Biology and Biochemistry, University of Bath, Bath, Somerset BA2 7AY, UK.
Trends Genet. 2003 Aug;19(8):417-22. doi: 10.1016/S0168-9525(03)00174-4.
An increasing number of studies report that functional divergence in duplicated genes is accompanied by gene expression changes, although the evolutionary mechanism behind this process remains unclear. Our genomic analysis on the yeast Saccharomyces cerevisiae shows that the number of shared regulatory motifs in the duplicates decreases with evolutionary time, whereas the total number of regulatory motifs remains unchanged. Moreover, genes with numerous paralogs in the yeast genome do not have especially low number of regulatory motifs. These findings indicate that degenerative complementation is not the sole mechanism behind expression divergence in yeast. Moreover, we found some evidence for the action of positive selection on cis-regulatory motifs after gene duplication. These results suggest that the evolution of functional novelty has a substantial role in yeast duplicate gene evolution.
越来越多的研究报告称，复制基因中的功能分化伴随着基因表达的变化，尽管这一过程背后的进化机制仍不清楚。我们对酿酒酵母的基因组分析表明，复制基因中共享调控基序的数量随进化时间而减少，而调控基序的总数保持不变。此外，酵母基因组中具有众多旁系同源基因的基因，其调控基序数量并非特别少。这些发现表明，退化互补不是酵母中表达分化背后的唯一机制。此外，我们发现了一些基因复制后顺式调控基序受到正选择作用的证据。这些结果表明，功能新颖性的进化在酵母复制基因进化中起着重要作用。
