Musso Gabriel, Zhang Zhaolei, Emili Andrew
Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada.
Trends Genet. 2007 Jun;23(6):266-9. doi: 10.1016/j.tig.2007.03.012. Epub 2007 Apr 10.
To investigate functional divergence of gene duplicates, we examined the protein-protein interactions and coexistence in complexes of paralogs resulting from an ancient whole-genome duplication in yeast. Strikingly, half the surveyed paralog pairs were found to be co-clustered in protein complexes, and were more conserved and highly expressed than non-co-clustered paralogs; however, their discordant expression patterns and conservation rates indicate differential regulation of subfunctionalized paralogs. These results highlight the value of protein complex membership in studying functional divergence among gene duplicates.
为了研究基因复制体的功能分化，我们检测了酵母中一次古老的全基因组复制所产生的旁系同源基因的蛋白质-蛋白质相互作用及在复合物中的共存情况。令人惊讶的是，在所调查的旁系同源基因对中，有一半被发现共同聚集在蛋白质复合物中，并且比非共同聚集的旁系同源基因更保守且表达量更高；然而，它们不一致的表达模式和保守率表明亚功能化旁系同源基因受到了差异调控。这些结果凸显了蛋白质复合物成员关系在研究基因复制体功能分化中的价值。
