正常乳腺组织女性中18F-FDG摄取与乳腺密度的关系。

Relationship between 18F-FDG uptake and breast density in women with normal breast tissue.

作者信息

Vranjesevic Duska, Schiepers Christiaan, Silverman Daniel H, Quon Andrew, Villalpando James, Dahlbom Magnus, Phelps Michael E, Czernin Johannes

机构信息

Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic/Nuclear Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-6942, USA.

出版信息

J Nucl Med. 2003 Aug;44(8):1238-42.

PMID:12902413

Abstract

UNLABELLED

Breast density affects the mammographic detectability of breast cancer. The study aimed to evaluate the impact of breast density on the (18)F-FDG uptake of normal breast tissue.

METHODS

The study population consisted of 45 women (median age, 54 y; age range, 42-77 y). All underwent whole-body (18)F-FDG PET for various indications other than breast cancer, and all underwent mammography within a mean of 6.6 +/- 4.9 mo of PET. On the basis of mammographic findings, breasts were categorized as extremely dense, heterogeneously dense, primarily fatty, or entirely fatty. Regions of interest were drawn on every PET image in which breast tissue was visualized. Average and peak standardized uptake values (SUVs) were calculated for the left and right breasts.

RESULTS

Mammography showed that 20 of the 45 women had heterogeneously dense breasts, 1 had extremely dense breasts, 20 had primarily fatty breasts, and 4 had entirely fatty breasts. In dense breasts, the average SUV was 0.39 +/- 0.05 (right breast) and 0.36 +/- 0.07 (left breast) and the peak SUV was 0.93 +/- 0.16 and 0.89 +/- 0.18, respectively. The average and peak SUVs were significantly lower for primarily fatty breasts than for dense breasts (P < 0.01). Peak and average SUVs of entirely fatty breasts also differed significantly from peak and average SUVs of dense and primarily fatty breasts (P < 0.01). The impact of hormonal status on SUV was significant but less than the impact of breast density. No significant relationship between average SUV or peak SUV and age or serum glucose level was observed.

CONCLUSION

Breast density and hormonal status affect the uptake of (18)F-FDG. Dense breasts exhibit, on average, significantly higher (18)F-FDG uptake than do nondense breasts. However, the highest peak SUV observed in dense breasts was 1.39, which is well below the SUV of 2.5 commonly used as a cutoff between benign and malignant tissue. Therefore, breast density is unlikely to affect the ability of (18)F-FDG PET to discriminate between benign and malignant breast lesions.

摘要

未标注

乳腺密度会影响乳腺癌的乳腺X线可检测性。本研究旨在评估乳腺密度对正常乳腺组织（18）F-FDG摄取的影响。

方法

研究人群包括45名女性（中位年龄54岁；年龄范围42 - 77岁）。所有患者均因非乳腺癌的各种适应证接受了全身（18）F-FDG PET检查，且均在PET检查后平均6.6±4.9个月内接受了乳腺X线摄影检查。根据乳腺X线摄影结果，将乳房分为极度致密型、不均匀致密型、主要为脂肪型或完全为脂肪型。在每幅可见乳腺组织的PET图像上绘制感兴趣区。计算左右乳房的平均和峰值标准化摄取值（SUV）。

结果

乳腺X线摄影显示，45名女性中20名乳房为不均匀致密型，1名乳房为极度致密型，20名乳房主要为脂肪型，4名乳房完全为脂肪型。在致密型乳房中，右侧乳房平均SUV为0.39±0.05，左侧乳房平均SUV为0.36±0.07，右侧乳房峰值SUV为0.93±0.16，左侧乳房峰值SUV为0.89±0.18。主要为脂肪型乳房的平均和峰值SUV显著低于致密型乳房（P < 0.01）。完全为脂肪型乳房的峰值和平均SUV也与致密型和主要为脂肪型乳房的峰值和平均SUV有显著差异（P < 0.01）。激素状态对SUV的影响显著，但小于乳腺密度的影响。未观察到平均SUV或峰值SUV与年龄或血糖水平之间存在显著关系。

结论

乳腺密度和激素状态会影响（18）F-FDG的摄取。致密型乳房平均显示出比非致密型乳房显著更高的（18）F-FDG摄取。然而，致密型乳房中观察到的最高峰值SUV为1.39，远低于通常用作良性和恶性组织分界值的SUV 2.5。因此，乳腺密度不太可能影响（18）F-FDG PET区分良性和恶性乳腺病变的能力。