Division of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Nucl Med. 2010 Mar;51(3):347-52. doi: 10.2967/jnumed.109.068718. Epub 2010 Feb 11.
Theoretically, the degree of (18)F-FDG uptake in the glandular tissues of the normal breast can affect the detection of breast cancer. The aim of this prospective study was to investigate relationships among age, menopausal state, and breast density and determine whether they affect (18)F-FDG uptake in normal glandular breast tissue.
Among 250 newly diagnosed breast cancer patients, 149 patients (mean age +/- SD, 50.9 +/- 9.70 y; range, 32-77 y) were analyzed because they had normal contralateral breasts confirmed by MRI, mammography, and (18)F-FDG PET examinations. PET images were acquired 60 +/- 2 min after the administration of (18)F-FDG (5.2 MBq/kg of body weight). The maximum and average standardized uptake value (SUVmax and SUVavg, respectively) of (18)F-FDG were calculated in the normal breast. Patients were divided into groups according to qualitative breast density and menopausal state. Descriptive statistics and 2-factorial analysis of covariance were used to assess the effects of qualitative breast density, menopausal state, and age on SUVmax and SUVavg. Pearson chi(2) was used to test the relationship between menopausal state and qualitative breast density.
The average age of patients with nondense breasts was significantly higher than that of patients with dense breasts (P < 0.01). Also, breast density related to menopausal state (P < 0.05). Dense breasts had an average SUVmax of 1.243 and mean SUVavg of 0.694, whereas nondense breasts had a mean SUVmax of 0.997 and mean SUVavg of 0.592. Analysis of covariance indicated that density and the linear effect of age were significant with regard to both SUVmax and SUVavg. After removing the linear effect of age, menopausal state had no effect on SUVmax and SUVavg.
(18)F-FDG uptake significantly decreases as age increases and breast density decreases. Age and qualitative breast density are independent factors and significantly affect (18)F-FDG uptake for both SUVmax and SUVavg. Menopausal state had no effect on SUVmax and SUVavg.
本前瞻性研究旨在探讨年龄、绝经状态和乳房密度之间的关系，并确定它们是否影响正常乳腺组织中 18F-FDG 的摄取。
在 250 例新诊断的乳腺癌患者中，对 149 例（平均年龄 ± SD，50.9 ± 9.70 岁；范围，32-77 岁）患者进行了分析，这些患者的对侧乳房通过 MRI、乳房 X 线摄影术和 18F-FDG PET 检查证实正常。PET 图像在 18F-FDG 给药后 60 ± 2 min 采集。计算正常乳房的最大和平均标准化摄取值（SUVmax 和 SUVavg）。根据定性乳房密度和绝经状态将患者分为组。采用描述性统计学和 2 因素协方差分析评估定性乳房密度、绝经状态和年龄对 SUVmax 和 SUVavg 的影响。采用 Pearson chi(2)检验绝经状态与定性乳房密度之间的关系。
非致密乳房患者的平均年龄明显高于致密乳房患者（P < 0.01）。此外，乳房密度与绝经状态相关（P < 0.05）。致密乳房的 SUVmax 平均为 1.243，SUVavg 平均为 0.694，而非致密乳房的 SUVmax 平均为 0.997，SUVavg 平均为 0.592。协方差分析表明，SUVmax 和 SUVavg 与密度和年龄的线性效应均显著相关。去除年龄的线性效应后，绝经状态对 SUVmax 和 SUVavg 无影响。
18F-FDG 的摄取随年龄增长和乳房密度降低而显著降低。年龄和定性乳房密度是独立的影响因素，对 SUVmax 和 SUVavg 均有显著影响。绝经状态对 SUVmax 和 SUVavg 无影响。
