肽核酸（PNA）对DNA中电子转移的控制。
Control of electron transfer in DNA by peptide nucleic acids (PNA).
作者信息
Tanabe K, Yoshida K, Dohno C, Okamoto A, Saito I
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.
出版信息
Nucleic Acids Symp Ser. 2000(44):35-6. doi: 10.1093/nass/44.1.35.
PMID:12903255
Abstract
The one-electron oxidation of PNA-DNA hybrid containing G-triplet sequence was examined. In DNA duplex G-triplet was selectively cleaved by oxidation, whereas in PNA-DNA hybrid cleavage efficiency was extremely lowered. These result suggested that cleavage efficiency of PNA-DNA hybrid was different from that of B-form DNA duplex.
摘要
对含有G-三联体序列的肽核酸-脱氧核糖核酸（PNA-DNA）杂交体的单电子氧化进行了研究。在脱氧核糖核酸双链体中，G-三联体通过氧化被选择性切割，而在PNA-DNA杂交体中，切割效率极低。这些结果表明，PNA-DNA杂交体的切割效率与B型脱氧核糖核酸双链体不同。
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