Zagursky Robert J, Olmsted Stephen B, Russell David P, Wooters Joe L
Wyeth Vaccines, West Henrietta, NY 14586, USA.
Expert Rev Vaccines. 2003 Jun;2(3):417-36. doi: 10.1586/14760584.2.3.417.
Genomic sequencing has provided a tremendous amount of information that can be useful in vaccine target identification. The sheer volume of information available necessitates the use of new research disciplines and techniques. Using bioinformatics, researchers sift through available data to identify appropriate candidates for biological analysis. This review provides an overview of available bioinformatic techniques for vaccine candidate identification and a few examples of how these techniques are being applied to specific bacterial pathogens.
基因组测序提供了大量可用于疫苗靶点识别的信息。现有信息的庞大规模使得有必要采用新的研究学科和技术。研究人员利用生物信息学，在现有数据中筛选，以确定适合进行生物学分析的候选对象。本文综述了用于疫苗候选物识别的现有生物信息学技术，并举例说明了这些技术如何应用于特定的细菌病原体。
