Malaterre H R, Lauribe P, Paganelli F, Ramond B, Lévy S
Service de cardiologie, CHU Nord, Marseille.
Arch Mal Coeur Vaiss. 1992 Sep;85(9):1335-7.
The effects of calcium inhibitors are not limited to the muscles and may affect other systems and cause varied side effects. Two cases of Parkinsonian syndrome occurring after starting therapy with calcium inhibitors (verapamil in one case and diltiazem in the other) are reported. Complete regression of the symptoms after withdrawing the drugs was strongly in favour of a causal relationship. The condition could be due to inhibition of the calcium channels in the central nervous system disturbing neurotransmission. This seems to be a rare side effect as there have only been three other reported cases of secondary extrapyramidal syndromes in the literature. However, a Parkinsonian syndrome is very invalidating and clinicians using this family of drugs should be aware of this possible complication.
钙通道阻滞剂的作用并不局限于肌肉，还可能影响其他系统并导致各种副作用。本文报告了两例在开始使用钙通道阻滞剂治疗后出现帕金森综合征的病例（一例使用维拉帕米，另一例使用地尔硫䓬）。停药后症状完全消退有力地支持了因果关系。这种情况可能是由于中枢神经系统钙通道受抑制干扰了神经传递。这似乎是一种罕见的副作用，因为文献中仅另有三例继发性锥体外系综合征的报告病例。然而，帕金森综合征会使人非常虚弱，使用这类药物的临床医生应意识到这种可能的并发症。
