Beard Keith
Expert Opin Drug Saf. 2003 May;2(3):211-3. doi: 10.1517/14740338.2.3.211.
Many diseases are now treatable with modern drugs. Elderly people, because they suffer from age-related illnesses, stand to gain the most, but they are also at risk from adverse drug reactions (ADRs). There are complex reasons for the increased frequency of ADRs, including poor prescribing, polypharmacy, altered drug handling and response, and poor compliance. Difficulties with interpretation of apparent ADR data include uncertainties about exposure and various confounding factors, for example, confounding by indication. Some simple prescribing guidelines can significantly help to minimise the extent of the clinical problem. These include:
现在，许多疾病都可用现代药物治疗。老年人由于患有与年龄相关的疾病，受益最大，但他们也面临药物不良反应（ADR）的风险。ADR发生频率增加有复杂的原因，包括处方不当、多种药物并用、药物处理和反应改变以及依从性差。解读明显的ADR数据存在困难，包括暴露情况的不确定性和各种混杂因素，例如适应症混杂。一些简单的处方指南可显著有助于将临床问题的严重程度降至最低。这些指南包括：
