Sergerie Yan, Boivin Guy
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec (Pavillon CHUL), and Université Laval, Québec, Canada.
J Clin Microbiol. 2003 Aug;41(8):3897-900. doi: 10.1128/JCM.41.8.3897-3900.2003.
A new in vitro system based on real-time PCR was developed for evaluation of human herpesvirus 8 susceptibility to antiviral agents. Cidofovir had the greatest inhibitory activity against HHV-8 (50% inhibitory concentration [IC(50)], 0.43 microM) followed by ganciclovir (2.61 microM), adefovir (18.00 microM), acyclovir (31.00 microM), and foscarnet (34.15 microM). The potential therapeutic efficacy for HHV-8 (i.e., peak serum drug level/IC(50)) is highest for cidofovir (167) and foscarnet (22).
开发了一种基于实时聚合酶链反应的新型体外系统,用于评估人疱疹病毒8对抗病毒药物的敏感性。西多福韦对HHV-8具有最大抑制活性(50%抑制浓度[IC(50)],0.43微摩尔),其次是更昔洛韦(2.61微摩尔)、阿德福韦(18.00微摩尔)、阿昔洛韦(31.00微摩尔)和膦甲酸钠(34.15微摩尔)。西多福韦(167)和膦甲酸钠(22)对HHV-8的潜在治疗效果(即血清药物峰值水平/IC(50))最高。