Wang Hong, Liu Bin, Jiang Jia-li
Department of Gastroenterology, Tong Ren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Apr;24(2):178-80.
To evaluate the features of gastroesophageal reflux disease (GERD) in elderly patients.
72 patients with GERD were investigated for the history of illness and the results of gastroscopy and 24 hours esophageal bile monitoring of 54 patients were simultaneously randomized to undergo ambulatory pH monitoring. The degrees of esophagitis were graded according to endoscopic findings.
Obesity was found in 48% of the elderly group (more than 65 years old) and 49% of the control group (less than 65 years old). There were longer acid and bile reflux time and higher frequency (65%) of hiatal hernia in the elderly, and more patients (35%) had complicated severe grade esophagitis. There were longer time of bile reflux and the higher incidence (76%) of both acid and bile reflux in elderly group than in control group (P < 0.05). But the acid reflux time (%) was similar in two groups (P > 0.05).
The GERD in elderly patients may be associated with obesity and hiatal hernia. The features of elderly GERD patients are high frequency of erosive esophagitis, and high frequency of both acid and bile reflux, as well as longer history of bile reflux time.
评估老年胃食管反流病(GERD)患者的特征。
对72例GERD患者进行病史调查及胃镜检查,同时对54例患者进行24小时食管胆汁监测,并随机进行动态pH监测。根据内镜检查结果对食管炎程度进行分级。
老年组(年龄大于65岁)肥胖患者占48%,对照组(年龄小于65岁)肥胖患者占49%。老年患者的酸和胆汁反流时间更长,食管裂孔疝发生率更高(65%),且更多患者(35%)合并重度食管炎。老年组胆汁反流时间长于对照组,酸和胆汁反流发生率高于对照组(76%)(P<0.05)。但两组酸反流时间(%)相似(P>0.05)。
老年GERD患者可能与肥胖和食管裂孔疝有关。老年GERD患者的特征为糜烂性食管炎发生率高、酸和胆汁反流发生率高以及胆汁反流时间长。