Wu B, Wang M, Li Y
Gastroenterology Department, South Building General Hospital of PLA, Beijing 100853, China.
Chin Med J (Engl). 1999 Apr;112(4):333-5.
To evaluate the relationship between the parameters of 24-hour esophageal pH monitoring and gastroesophageal reflux disease (GERD) among elderly subjects.
Twenty-four-hour esophageal pH monitoring was carried out in 20 elderly subjects without apparent GERD symptoms (controls) and 69 suspected GERD subjects.
Normal values of the parameters from 20 elderly controls were obtained. Percent of total time, percent of supine time and percent of upright time in which the pH was < 4 (indicating reflux) were less than 3.3%, 1.4%, 5.5%, respectively. The number of reflux episodes and episodes lasting longer than 5 minutes were less than 65 and 2 times respectively. The values obtained in 66 GERD suspected subjects were significantly different from those in normal controls. The differences of reflux parameters between the esophagitis group and non-esophagitis group, such as percent of total time with pH < 4, percent of supine time with pH < 4 and number of reflux lasting longer than 5 minutes were also significant.
About 51.6% patients (34/66) with reflux symptoms but without endoscopic evidence of esophagitis were definitely diagnosed as GERD by esophageal pH monitoring. Duration of esophageal acid exposure correlated with the severity of GERD.
评估老年受试者24小时食管pH监测参数与胃食管反流病（GERD）之间的关系。
对20名无明显GERD症状的老年受试者（对照组）和69名疑似GERD受试者进行24小时食管pH监测。
获得了20名老年对照组受试者参数的正常值。pH<4（表明反流）的总时间百分比、仰卧位时间百分比和直立位时间百分比分别小于3.3%、1.4%、5.5%。反流发作次数和持续超过5分钟的发作次数分别少于65次和2次。66名疑似GERD受试者获得的值与正常对照组有显著差异。食管炎组和非食管炎组之间的反流参数差异，如pH<4的总时间百分比、pH<4的仰卧位时间百分比和持续超过5分钟的反流次数也有显著差异。
约51.6%有反流症状但无食管炎内镜证据的患者（34/66）通过食管pH监测被明确诊断为GERD。食管酸暴露持续时间与GERD的严重程度相关。
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