Jia G Q, Chen Z Q, Li H L, Cui P G, Xu W Y
Department of Clinical Research, Institute of Dermatology, CAMS, PUMC, Nanjing 210042, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Apr;23(2):173-5.
To investigate the better regimen of combined cyclophosphamide pulse therapy with corticosteroids in the treatment of Pemphigus.
Intravenous cyclophosphamide was given weekly in a dosage of 600 mg to those Pemphigus patients whose conditions couldn't be improved by corticosteroids (oral prednisone 1.2-1.5 mg/kg/d) alone.
Ten patients with Pemphigus received weekly cyclophosphamide therapy in addition to corticosteroid. Patients conditions improved quickly, without side effects.
Cyclophosphamide weekly pulse therapy combined with corticosteroids is a good regimen in the treatment of Pemphigus.
探讨环磷酰胺脉冲疗法联合糖皮质激素治疗天疱疮的更佳方案。
对于单用糖皮质激素（口服泼尼松1.2 - 1.5mg/kg/d）病情无改善的天疱疮患者，每周静脉给予环磷酰胺，剂量为600mg。
10例天疱疮患者在接受糖皮质激素治疗的基础上，每周加用环磷酰胺治疗。患者病情迅速改善，且无副作用。
环磷酰胺每周脉冲疗法联合糖皮质激素是治疗天疱疮的良好方案。
