Institute of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia.
Am J Clin Dermatol. 2010;11(2):123-9. doi: 10.2165/11311150-000000000-00000.
Autoimmune pemphigus is a group of severe blistering diseases. Although corticosteroids have dramatically altered the prognosis of pemphigus, morbidity and mortality resulting from the adverse effects of systemic corticosteroids remain high. Dexamethasone-cyclophosphamide pulse (DCP) therapy was introduced to diminish the adverse effects of prolonged conventional daily dose regimens.
To report our experience with the use of the DCP regimen in patients with autoimmune pemphigus.
In the period 1998-2002, 72 patients with various forms of autoimmune pemphigus treated with DCP therapy were included, of whom 36 patients were previously treated with conventional corticosteroid therapy, and 36 were newly diagnosed patients.
Of the 72 patients, 43 completed treatment, while 13 patients did not respond adequately to the treatment and continued with the conventional daily regimen, nine patients were lost to follow-up, and seven patients died. Two of these deaths were probably a consequence of DCP therapy.
DCP regimen is a beneficial treatment for patients with pemphigus, sparing the adverse effects of conventional regimens.
自身免疫性天疱疮是一组严重的水疱性疾病。尽管皮质类固醇显著改变了天疱疮的预后，但由于全身皮质类固醇的不良反应导致的发病率和死亡率仍然很高。地塞米松-环磷酰胺脉冲（DCP）治疗的引入是为了减少长期常规日剂量方案的不良反应。
报告我们在自身免疫性天疱疮患者中使用 DCP 方案的经验。
在 1998-2002 年期间，纳入了 72 例接受 DCP 治疗的各种形式自身免疫性天疱疮患者，其中 36 例患者之前接受过常规皮质类固醇治疗，36 例为新诊断患者。
在 72 例患者中，43 例完成了治疗，而 13 例对治疗反应不充分，继续接受常规日剂量方案，9 例失访，7 例死亡。其中两例死亡可能是 DCP 治疗的结果。
DCP 方案是天疱疮患者的有益治疗方法，可以避免常规方案的不良反应。
