Su W, Ren F Q
Clinical Laboratory, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Apr;23(2):196-8.
To investigate the factors that influence the consistency of international normalized ratio (INR) of prothrombin time.
Using the same automated blood coagulation analyzer and INR calibration plasma with two different types of prothrombin time (PT) reagent to assay the INR values of 19 controls (group 1), 12 patients who took long-term anticoagulant orally (group 2), 12 patients who took it at the first time (group 3) and 8 patients who took long-term anticoagulant together with cephalosporin N (group 4).
The two kinds of reagents gave quite different INR values in all four groups (P < 0.01). The INR difference in group 3 (0.23 +/- 0.07, n = 12) was larger than that in group 2 (0.51 +/- 0.20, n = 12) (P < 0.01). The difference in group 4 (0.61 +/- 0.21, n = 8) was larger than that in group 2 (P < 0.01).
The factors that may influence INR consistency are the source and sensitivity of the reagents, as well as the period of the anti coagulant been taken and the other drugs taken at the same time.
探讨影响凝血酶原时间国际标准化比值（INR）一致性的因素。
使用同一台自动血液凝固分析仪和INR校准血浆，采用两种不同类型的凝血酶原时间（PT）试剂，检测19例对照者（1组）、12例长期口服抗凝剂的患者（2组）、12例首次服用抗凝剂的患者（3组）和8例长期服用抗凝剂并同时服用头孢菌素N的患者（4组）的INR值。
两种试剂在所有四组中得出的INR值差异很大（P<0.01）。3组（0.23±0.07，n=12）的INR差异大于2组（0.51±0.20，n=12）（P<0.01）。4组（0.61±0.21，n=8）的差异大于2组（P<0.01）。
可能影响INR一致性的因素包括试剂的来源和灵敏度，以及服用抗凝剂的时间和同时服用的其他药物。
