Misceo Doriana, Ventura Mario, Eder Verena, Rocchi Mariano, Archidiacono Nicoletta
Sezione di Genetica, DAPEG, Via Amendola 165/A 70126 Bari, Italy.
Chromosome Res. 2003;11(4):323-6. doi: 10.1023/a:1024087823030.
A study was made of the organization of the chromosome orthologous to HSA16 in primates using a panel of 8 BAC probes spanning human chromosome 16. The probes were used in FISH experiments on great apes and on representatives of the Old World monkeys, New World monkeys, and lemurs. The domestic cat was used as an outgroup. The results indicate that 16p and 16q were separate chromosomes in a primate ancestor. They fused in a Catarrhini ancestor giving rise to the present day form found in HSA, great apes, and Old World monkeys. Several rearrangements were found in New World monkeys.
利用一组跨越人类16号染色体的8个BAC探针，对灵长类动物中与人类16号染色体直系同源的染色体组织进行了研究。这些探针被用于对大猩猩、旧世界猴、新世界猴和狐猴的代表进行荧光原位杂交实验。家猫被用作外类群。结果表明，在灵长类动物的祖先中，16号染色体短臂（16p）和长臂（16q）是两条分开的染色体。它们在狭鼻猿祖先中发生融合，形成了人类、大猩猩和旧世界猴中现今的形式。在新世界猴中发现了几次重排。
