Banczerowski P, Csaba Z, Csernus V, Gerendai I
Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary.
J Endocrinol Invest. 2003 May;26(5):429-34. doi: 10.1007/BF03345198.
The effect of right- and left-sided intra-amygdaloid injection of kainic acid on the hypothalamo-hypophyseal-testicular axis was studied in rats. Both right- and left-sided injection of the neurotoxin into the amygdala resulted in a significant decrease in basal testosterone secretion in vitro of both testes and in serum testosterone concentration. In addition, left-sided administration of kainic acid significantly suppressed serum luteinizing hormone level, while right-sided intervention did not alter this parameter. The results of the present study provide further evidence on the involvement of the amygdala in the control of testicular steroidogenesis. Furthermore, the observations suggest functional asymmetry of the amygdala concerning the mechanism of suppressed testosterone secretion.
研究了在大鼠杏仁核内右侧和左侧注射海藻酸对下丘脑-垂体-睾丸轴的影响。向杏仁核内右侧和左侧注射这种神经毒素均导致双侧睾丸体外基础睾酮分泌以及血清睾酮浓度显著降低。此外，左侧注射海藻酸显著抑制血清黄体生成素水平，而右侧干预未改变该参数。本研究结果为杏仁核参与睾丸类固醇生成的调控提供了进一步证据。此外，这些观察结果提示杏仁核在睾酮分泌受抑制机制方面存在功能不对称性。
