Mishima Masanori, Glotzer Michael
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria.
Curr Biol. 2003 Aug 5;13(15):R589-91. doi: 10.1016/s0960-9822(03)00521-9.
Two complexes localize to the central spindle and regulate completion of cytokinesis: one, centralspindlin, contains a kinesin-like protein and a Rho-family GAP; the second contains Aurora B kinase. Aurora B kinase is known to regulate localization of centralspindlin and may regulate the activity of the RhoGAP component of centralspindlin.
一种是中央纺锤体蛋白复合物,包含一种类驱动蛋白和一种Rho家族GAP;另一种含有极光激酶B。已知极光激酶B可调节中央纺锤体蛋白复合物的定位,并可能调节中央纺锤体蛋白复合物中RhoGAP组分的活性。