Sarsilmaz Mustafa, Songur Ahmet, Ozyurt Hüseyin, Kuş Ilter, Ozen Oğuz Aslan, Ozyurt Birsen, Söğüt Sadik, Akyol Omer
Department of Anatomy, Faculty of Medicine, Firat University, Dekanlik Binasi, Elaziğ, Turkey.
Prostaglandins Leukot Essent Fatty Acids. 2003 Oct;69(4):253-9. doi: 10.1016/s0952-3278(03)00107-8.
Omega-3 (omega-3) is an essential fatty acid (EFA) found in large amounts in fish oil. It contains eicosapentaenoic acid and docosahexaenoic acid (DHA). DHA is one of the building structures of membrane phospholipids of brain and necessary for continuity of neuronal functions. Evidences support the hypothesis that schizophrenia may be the result of increased reactive oxygen species mediated neuronal injury. Recent reports also suggest the protective effect of omega-3 EFA against neuropsychiatric disorders including schizophrenia. This study proposed to assess the changes in antioxidant enzyme and oxidant parameters in the corpus striatum (CS) of rats fed with omega-3 EFA diet (0.4g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 were decapitated under ether anesthesia, and CS was removed immediately. Thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) levels as well as total superoxide dismutase (t-SOD) and xanthine oxidase (XO) enzyme activities in the CS were measured. Rats treated with omega-3 EFA had significantly lower values of TBARS (P<0.001), NO (P<0.002) and XO (P<0.005) whereas higher values of t-SOD enzyme activity (P<0.002) than the control rats. These results indicate that omega-3 EFA rich fish oil diet reduces some oxidant parameters in CS. This may be revealed by means of reduced CS TBARS levels as an end product of lipid peroxidation of membranes in treated rats. Additionally, reduced XO activity and NO levels may support this notion. On the other hand, although the mechanism is not clear, omega-3 EFA may indirectly enhance the activity of antioxidant enzyme t-SOD. Taken together, this preliminary animal study provides strong support for a therapeutic effect of omega-3 EFA supplemented to classical neuroleptic regimen in the treatment of schizophrenic symptoms and tardive dyskinesia.
Omega-3（ω-3）是一种必需脂肪酸（EFA），大量存在于鱼油中。它含有二十碳五烯酸和二十二碳六烯酸（DHA）。DHA是脑细胞膜磷脂的组成结构之一，对神经元功能的持续运作至关重要。有证据支持这样一种假说，即精神分裂症可能是活性氧介导的神经元损伤增加所致。近期报告还表明ω-3必需脂肪酸对包括精神分裂症在内的神经精神疾病具有保护作用。本研究旨在评估喂食ω-3必需脂肪酸饮食（0.4克/千克/天）30天的大鼠纹状体（CS）中抗氧化酶和氧化参数的变化。八只对照大鼠和九只喂食ω-3的大鼠在乙醚麻醉下断头，然后立即取出CS。测量了CS中的硫代巴比妥酸反应性物质（TBARS）和一氧化氮（NO）水平以及总超氧化物歧化酶（t-SOD）和黄嘌呤氧化酶（XO）的酶活性。与对照大鼠相比，用ω-3必需脂肪酸处理的大鼠的TBARS（P<0.001）、NO（P<0.002）和XO（P<0.005）值显著更低，而t-SOD酶活性值更高（P<0.002）。这些结果表明富含ω-3必需脂肪酸的鱼油饮食可降低CS中的一些氧化参数。这可能表现为处理后大鼠中作为膜脂质过氧化终产物的CS中TBARS水平降低。此外，XO活性和NO水平降低可能支持这一观点。另一方面，尽管机制尚不清楚，但ω-3必需脂肪酸可能间接增强抗氧化酶t-SOD的活性。综上所述，这项初步的动物研究为在经典抗精神病药物治疗方案中补充ω-3必需脂肪酸治疗精神分裂症症状和迟发性运动障碍的治疗效果提供了有力支持。
