Higginson Christopher I, King David S, Levine Dawn, Wheelock Vicki L, Khamphay Nuny O, Sigvardt Karen A
Center for Neuroscience, University of California, Davis, CA 95616, USA.
Brain Cogn. 2003 Aug;52(3):343-52. doi: 10.1016/s0278-2626(03)00180-5.
A growing body of evidence suggests that the various cognitive symptoms found in Parkinson's disease (PD) are secondary to executive dysfunction. Studies addressing this possibility for memory impairment specifically have not included measures of working memory nor have they ruled-out potential mediating variables such as overall level of cognitive impairment or depression. The purpose of this study was to include measures of these variables in determining the relationship between multiple aspects of executive function and delayed verbal recall in 32 idiopathic PD patients. Results were consistent with the original hypothesis and further suggest that working memory is a key factor in recall memory and may mediate the relationship between other executive measures and recall in PD.
越来越多的证据表明，帕金森病（PD）中发现的各种认知症状继发于执行功能障碍。专门针对记忆障碍这种可能性的研究既未纳入工作记忆测量，也未排除潜在的中介变量，如认知障碍的总体水平或抑郁。本研究的目的是纳入这些变量的测量，以确定32例特发性PD患者执行功能的多个方面与延迟言语回忆之间的关系。结果与原假设一致，进一步表明工作记忆是回忆记忆的关键因素，可能介导PD中其他执行测量与回忆之间的关系。
