Dhir Karan, Sciubba James, Tufano Ralph P
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins Medical Center, 601 N. Caroline Street, Baltimore, MD 21287-0910, USA.
Oral Oncol. 2003 Oct;39(7):736-41. doi: 10.1016/s1368-8375(03)00036-8.
The maxilla is an unusual site for an ameloblastoma, and certainly for an ameloblastic carcinoma. Ameloblastomas are considered as benign, yet locally aggressive neoplasms in the vast majority of cases. However, very rarely, these tumors demonstrate a clinical course of malignancy. Recently, a classification system was published differentiating between malignant odontogenic carcinoma variants. The two such forms include malignant ameloblastoma, and ameloblastic carcinoma. In the differential diagnosis, the designation of malignant ameloblastoma is reserved for lesions that, despite their benign histology, metastasize as well-differentiated cells. The diagnosis of ameloblastic carcinoma is reserved for tumors that demonstrate a malignant morphologic appearance, regardless of whether metastasis is a proven fact at the time of discovery and treatment. We discuss the presentation, pathology, and treatment of the 18th case of a maxillary ameloblastic carcinoma in the literature.
上颌骨是成釉细胞瘤，尤其是成釉细胞癌的罕见发病部位。绝大多数情况下，成釉细胞瘤被认为是良性但具有局部侵袭性的肿瘤。然而，这些肿瘤极少表现出恶性的临床病程。最近，发布了一种区分恶性牙源性癌变体的分类系统。其中两种形式包括恶性成釉细胞瘤和成釉细胞癌。在鉴别诊断中，恶性成釉细胞瘤这一名称用于尽管组织学表现为良性，但却以分化良好的细胞发生转移的病变。成釉细胞癌的诊断用于那些表现出恶性形态学外观的肿瘤，无论在发现和治疗时转移是否已被证实。我们讨论了文献中第18例上颌骨成釉细胞癌的临床表现、病理及治疗情况。
