Fitzpatrick S G, Hirsch S A, Listinsky C M, Lyu D J-H, Baur D A
Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.
Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Apr;119(4):e241-5. doi: 10.1016/j.oooo.2014.09.028. Epub 2014 Sep 30.
Ameloblastic carcinoma and ghost cell odontogenic carcinoma are rare malignancies arising in odontogenic epithelium within the jaws. Gardner syndrome is a multifaceted autosomal dominant condition, which results in multiple dentofacial anomalies along with premalignant colon polyp formation and tumor formation in the skin and other organs. We report a case of ameloblastic carcinoma with features of ghost cell odontogenic carcinoma and extensive clear cell change and melanin pigmentation in a patient with clinical features of Gardner syndrome. To the best of our knowledge, odontogenic carcinoma arising in a patient with features of Gardner syndrome has not been reported previously. The clinical, radiographic, and histologic features of the case are discussed along with a review of the relevant literature.
成釉细胞癌和牙源性影细胞癌是发生于颌骨牙源性上皮的罕见恶性肿瘤。加德纳综合征是一种多方面表现的常染色体显性疾病，可导致多种牙颌面异常，同时伴有结肠息肉癌前病变以及皮肤和其他器官的肿瘤形成。我们报告一例具有牙源性影细胞癌特征、广泛透明细胞改变和黑色素沉着的成釉细胞癌病例，该患者具有加德纳综合征的临床特征。据我们所知，此前尚未有关于具有加德纳综合征特征患者发生牙源性癌的报道。本文讨论了该病例的临床、影像学和组织学特征，并对相关文献进行了综述。
