通过24小时动态pH监测综合酸度评估年龄和性别对胃酸分泌的影响。

Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring.

作者信息

Shih Grace L, Brensinger Colleen, Katzka David A, Metz David C

机构信息

Division of Gastroenterology, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania 19104, USA.

出版信息

Am J Gastroenterol. 2003 Aug;98(8):1713-8. doi: 10.1111/j.1572-0241.2003.07586.x.

DOI:10.1111/j.1572-0241.2003.07586.x

PMID:12907323

Abstract

OBJECTIVES

Earlier studies have suggested that gastric acid secretion declines with age. Integrated acidity (IA) calculated from ambulatory 24-h pH studies provides an estimation of gastric acid secretion that is less cumbersome than nasogastric aspiration. The aim of this study was to calculate IA as a function of age and gender.

METHODS

In a retrospective study, 753 ambulatory 24-h pH studies from 1994 to 2001 were analyzed. Subjects were classified according to nine age groups: <35 yr (n = 124), 35-39 yr (n = 90), 40-44 yr (n = 92), 45-49 yr (n = 111), 50-54 yr (n = 96), 55-59 yr (n = 61), 60-64 yr (n = 59), 65-69 yr (n = 42), and > or =70 yr (n = 64). Basal integrated acidity (BIA) was defined as IA between 12 midnight and 8 AM when no meals were consumed. Daytime and nocturnal IA/h was measured from 8 AM to 8 PM and from 8 PM to 8 AM. Postprandial IA (PIA) was measured for 2 h after the largest meal peak in each patient.

RESULTS

Gender distribution was similar between groups (chi(2) = 6.42, 3 df, p = 0.093). Mean gastric pH was similar between genders (2.96 +/- 1.36 women; 3.01 +/- 1.42 men; p = 0.71). Women and men had similar BIA (361.1 +/- 384.1 vs 434.6 +/- 436.6 mmol/L/h, p = 0.10), daytime IA (33.5 +/- 33.0 vs 34.1 +/- 33.7 mmol/L, p = 0.90) and nocturnal IA (43.3 +/- 42.1 vs 48.0 +/- 46.6 mmol/L, p = 0.42), and PIA (38.2 +/- 58.7 vs 36.0 +/- 58.5 mmol/L/h, p = 0.47). Mean gastric pH, daytime and nocturnal IA, BIA, and PIA did not differ between age groups (p > 0.1). None of the parameters studied had a linear association with age (mean gastric pH, r = 0.106; BIA, r = -0.124; daytime IA, r = -0.046; nocturnal IA, r = -0.104; PIA, r = -0.117).

CONCLUSIONS

Based on this study, we conclude that IA is unaffected by gender or age.

摘要

目的

早期研究表明胃酸分泌随年龄增长而下降。通过动态24小时pH值研究计算得出的综合酸度（IA）可用于评估胃酸分泌，相较于鼻胃管抽吸法，该方法更为简便。本研究旨在计算IA与年龄和性别的函数关系。

方法

在一项回顾性研究中，分析了1994年至2001年期间753例动态24小时pH值研究。受试者按九个年龄组分类：<35岁（n = 124）、35 - 39岁（n = 90）、40 - 44岁（n = 92）、45 - 49岁（n = 111）、50 - 54岁（n = 96）、55 - 59岁（n = 61）、60 - 64岁（n = 59）、65 - 69岁（n = 42）以及≥岁（n = 64）。基础综合酸度（BIA）定义为午夜12点至上午8点未进食时的IA。白天和夜间每小时IA分别从上午8点至晚上8点以及晚上8点至上午8点进行测量。每位患者在每餐最大峰值后2小时测量餐后IA（PIA）。

结果

各年龄组间性别分布相似（χ² = 6.42，自由度为3，p = 0.093）。男女平均胃pH值相似（女性为2.96 ± 1.36；男性为3.01 ± 1.42；p = 0.71）。女性和男性的BIA（361.1 ± 384.1与434.6 ± 436.6 mmol/L/h，p = 0.10）、白天IA（33.5 ± 33.0与34.1 ± 33.7 mmol/L，p = 0.90）、夜间IA（43.3 ± 42.1与48.0 ± 46.6 mmol/L，p = 0.42）以及PIA（38.2 ± 58.7与36.0 ± 58.5 mmol/L/h，p = 0.47）均相似。各年龄组间平均胃pH值、白天和夜间IA、BIA以及PIA无差异（p > 0.1）。所研究的参数均与年龄无线性关联（平均胃pH值，r = 0.106；BIA，r = −0.124；白天IA，r = −0.046；夜间IA，r = −0.104；PIA，r = −0.117）。