Hacker Jörg, Hentschel Ute, Dobrindt Ulrich
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Science. 2003 Aug 8;301(5634):790-3. doi: 10.1126/science.1086802.
Recent insights into bacterial genome organization and function have improved our understanding of the nature of pathogenic bacteria and their ability to cause disease. It is becoming increasingly clear that the bacterial chromosome constantly undergoes structural changes due to gene acquisition and loss, recombination, and mutational events that have an impact on the pathogenic potential of the bacterium. Even though the bacterial genome includes additional genetic elements, the chromosome represents the most important entity in this context. Here, we will show that various processes of genomic instability have an influence on the many manifestations of infectious disease.
最近对细菌基因组组织和功能的深入了解，增进了我们对病原菌本质及其致病能力的认识。越来越明显的是，由于基因的获得与丢失、重组以及对细菌致病潜力有影响的突变事件，细菌染色体不断发生结构变化。尽管细菌基因组包含其他遗传元件，但在这种情况下，染色体是最重要的实体。在这里，我们将表明基因组不稳定的各种过程对传染病的多种表现形式都有影响。
