Wren B W
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Nat Rev Genet. 2000 Oct;1(1):30-9. doi: 10.1038/35049551.
Genome analysis of microbial pathogens has provided unique insights into their virulence, host adaptation and evolution. Common themes have emerged, including lateral gene transfer among enteric pathogens, genome decay among obligate intracellular pathogens and antigenic variation among mucosal pathogens. The advent of post-genomic approaches and the sequencing of the human genome will enable scientists to investigate the complex and dynamic interplay between host and pathogen. This wealth of information will catalyse the development of new intervention strategies to reduce the burden of microbial-related disease.
对微生物病原体的基因组分析为了解它们的毒力、宿主适应性和进化提供了独特的视角。一些共同的主题已经浮现出来，包括肠道病原体之间的横向基因转移、专性胞内病原体的基因组衰退以及黏膜病原体的抗原变异。后基因组方法的出现以及人类基因组测序将使科学家能够研究宿主与病原体之间复杂而动态的相互作用。这些丰富的信息将推动新干预策略的开发，以减轻微生物相关疾病的负担。
