Salyer K E, Gendler E, Menendez J L, Simon T R, Kelly K M, Bardach J
Humana International Craniofacial Institute, Humana Hospital-Medical City Dallas, Texas.
J Craniofac Surg. 1992 Sep;3(2):55-62. doi: 10.1097/00001665-199209000-00002.
Between July 1990 and September 1991, demineralized perforated allogeneic bone implants (Pacific Coast Tissue Bank, Los Angeles, CA) were placed in 72 patients. Because many patients received more than one implant, a total of 248 implants were used in 80 procedures. The technology of processing demineralized bone implants is described in detail. All patients were operated on by one surgeon (K.E.S.) at the Humana Craniofacial Institute in Dallas, Texas. Forty-one patients had craniofacial deformities, 16 had secondary deformities following cleft lip and palate repair, 8 had bony defects following removal of tumors, and 10 had various skeletal deformities following trauma. Of the 72 patients, 6 had two surgical procedures during which additional implants were inserted. Implants placed in the cranial vault and the maxillary complex, including alveolar grafts, were inlay grafts, whereas implants placed in the orbital, nasal, paranasal, temporal, and malar areas were onlay grafts used for contouring, augmentation, or both. Complications were limited to delayed wound healing in 6 patients. According to our observations, demineralized perforated bone implants represent an encouraging alternative to autogenous bone grafting. Further clinical and experimental studies are necessary to obtain more information about this material.
1990年7月至1991年9月期间，72例患者植入了脱矿质多孔异体骨移植物（加利福尼亚州洛杉矶市太平洋海岸组织库）。由于许多患者接受了不止一个移植物，因此在80次手术中共使用了248个移植物。详细描述了脱矿质骨移植物的加工技术。所有患者均由得克萨斯州达拉斯市Humana颅面研究所的一名外科医生（K.E.S.）进行手术。41例患者患有颅面畸形，16例在唇腭裂修复后出现继发性畸形，8例在肿瘤切除后出现骨缺损，10例在创伤后出现各种骨骼畸形。72例患者中有6例接受了两次手术，期间插入了额外的移植物。放置在颅顶和上颌复合体（包括牙槽植骨）的移植物为嵌体移植，而放置在眼眶、鼻、鼻旁、颞和颧区的移植物为覆盖移植，用于塑形、增大或两者兼用。并发症仅限于6例患者伤口愈合延迟。根据我们的观察，脱矿质多孔骨移植物是自体骨移植的一种令人鼓舞的替代方法。需要进一步的临床和实验研究以获取有关这种材料的更多信息。
