Miyake Katsuya, McNeil Paul L
Department of Cellular Biology and Anatomy and the Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA.
Crit Care Med. 2003 Aug;31(8 Suppl):S496-501. doi: 10.1097/01.CCM.0000081432.72812.16.
To concisely review the field of cell plasma membrane disruption (torn cell surface) and repair.
Plasma membrane disruption is a common form of cell injury under physiologic conditions, after trauma, in certain muscular dystrophies, and during certain forms of clinical intervention. Rapid repair of a disruption is essential to cell survival and involves a complex and active cell response that includes membrane fusion and cytoskeletal activation. Tissues, such as cardiac and skeletal muscle, adapt to a disruption injury by hypertrophying. Cells adapt by increasing the efficiency of their resealing response.
Plasma membrane disruption is an important cellular event in both health and disease. The disruption repair mechanism is now well understood at the cellular level, but much remains to be learned at the molecular level. Cell and tissue level adaptational responses to the disruption either prevent its further occurrence or facilitate future repairs. Therapeutically useful drugs might result if, using this accumulating knowledge, chemical agents can be developed that can enhance repair or adaptive responses.
简要综述细胞质膜破坏（细胞表面撕裂）及修复领域。
质膜破坏是生理条件下、创伤后、某些肌肉营养不良症以及某些临床干预过程中常见的细胞损伤形式。快速修复破坏对于细胞存活至关重要，且涉及复杂而活跃的细胞反应，包括膜融合和细胞骨架激活。心脏和骨骼肌等组织通过肥大来适应破坏损伤。细胞则通过提高其重新封闭反应的效率来适应。
质膜破坏在健康和疾病中都是重要的细胞事件。破坏修复机制在细胞水平上现已得到充分理解，但在分子水平上仍有许多有待了解之处。细胞和组织水平对破坏的适应性反应要么防止其进一步发生，要么促进未来的修复。如果利用这些不断积累的知识开发出能够增强修复或适应性反应的化学试剂，可能会产生具有治疗作用的药物。
