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[血管加压素的表面活性及其与人工膜和生物膜的相互作用]

[The surface activity of vasopressin and its interaction with artificial and biological membranes].

作者信息

Ostrovskaia G V, Shevchenko S I, Mogilevich B R, Rybal'chenko R V, Rybal'chenko V K

出版信息

Biull Eksp Biol Med. 1992 Nov;114(11):470-3.

PMID:1290812
Abstract

It was determined that vasopressin has surface active properties and in nanomolic concentrations is capable to incorporate in lipoprotein monolayers which are formed from myocytes plasma membranes. By means of pH-metric and fluorescent analysis it was shown that vasopressin interacts with other membrane structures which have no specific receptors--phosphatidylcholinic liposomes and vesicles of sarcoplasmic reticulum of skeletal muscles causing increasing permeability of phospholipid bilayer for Ca2+ ions.

摘要

已确定血管加压素具有表面活性特性,在纳摩尔浓度下能够掺入由心肌细胞质膜形成的脂蛋白单层中。通过pH测量和荧光分析表明,血管加压素与其他没有特异性受体的膜结构相互作用,即磷脂酰胆碱脂质体和骨骼肌肌浆网囊泡,导致磷脂双层对Ca2+离子的通透性增加。

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