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[来自皮肤的影响培养的人角质形成细胞增殖和分化的生物活性物质]

[Biologically active substances from the skin that influence the proliferation and differentiation of cultured human keratinocytes].

作者信息

Lopukhin Iu M, Arion V Ia, Ivanova V F, Belova O V, Kapitanov A B

出版信息

Biull Eksp Biol Med. 1992 Nov;114(11):473-5.

PMID:1290813
Abstract

Three fractions of biologically active substances of human skin varying in molecular weight (F1 > 15 kD, F2 1.4-15 kD, F3 < 1.4 kD) were tested in primary and regenerating cultures of human epidermal keratinocytes. F1 and F3 caused stimulation of keratinocyte proliferation, F2 inhibited proliferation and enhanced terminal differentiation of epidermal cells.

摘要

对人皮肤中分子量不同的三种生物活性物质组分(F1 > 15 kD,F2 1.4 - 15 kD,F3 < 1.4 kD)在人表皮角质形成细胞的原代培养和再生培养中进行了测试。F1和F3刺激角质形成细胞增殖,F2抑制增殖并增强表皮细胞的终末分化。

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